They were admitted to hospitals in Greater Manchester and Liverpool between Sunday and Monday but died while receiving treatment.
Although post mortem results are yet to be delivered, police have issued a statement warning people of about potentially killer pills currently in circulation.
The pills are said to be heart shaped and come in purple, yellow, green and blue colours.
Det Chief Insp Howard Millington from Greater Manchester Police said: “Our main concern is that there may be a contaminated quantity of illegal drugs and if this goes unchecked it could result in further deaths.
"If you are suffering adverse effects after taking one of these tablets I would advise you to go to hospital for a check up."
It's also being reported that police are aware of other people that have been hospitalized over the weekend and have launched an investigation."
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